New minimal invasive method in the treatment of morbid obesity: application of magnetic gastro-jejunostomy and gastro-duodenal double balloon. Experimental results

Szülőkategória: KUTATÁSI TÉMÁK
10. 01. 09
Módosítás: 01 december 2016

Gerő Dániel 1, Lukovich Péter dr.2,Kecskédi Bence1, Bata Pál dr. 3, Tari Krisztina 2, Kupcsulik Péter dr. 2
Magyar Gasztroenterológiai Társaság 50. Nagygyűlése, Tihany, 2008. június 6-11.

Semmelweis Egyetem, Általános Orvostudományi Kar (1), I.sz. Sebészeti Klinika (2), Budapest


Introduction: Number of patients with morbid obesity (BMI>40kg/m 2 ) rises worldwide; current surgical treatments act by virtue of decreasing food absorption and/or increasing satiety. Both methods bear complications (malnutrition, anemia, vitamin deficiency), further interventions shall be indicated.

Background and aim: Our research team works on expanding the potential applications of flexible endoscopy and magnetic surgery. The aim was to work out a totally minimal invasive method to avoid the risk of surgical intervention.

Method: We proved formerly that gastro-jejunal bypass is formable with magnets. We simplified present experiment with gastro-jejunostomy and used a double, gastro-duodenal balloon to close the pylorus. Balloons contained water, x-ray contrast material and methylene blue.

Male 250 g Whistar rats were divided in 5 groups (n=5).

1. group: control group

2. group: gastrotomy, gastric balloon (2.5cm 3 )

3. group: gastro-jejunal anastomosis

4. group: gastro-jejunal anastomosis, gastric balloon

5. group: gastro-jejunal anastomosis, gastro-duodenal balloon (0.25 cm 3 duodenal part, 2.5cm 3 gastric part)

After operations animals received 5 gram/day fodder in self cage. We measured periodically body weight and quantity of rest fodder for 3 post-operative weeks. We checked the position of balloons with native x-ray and CT. The effect of the balloon on the mucosa was evaluated by histology.

Results: In average, control animals gained 25g weight every second day, 4g fodder was left. Other groups gained less, fifth group the least (between 0-10g).

Conclusion: Surgical bypass procedure performed in a minimal invasive fashion (anastomosis created with magnets, stomach closed by a gastro-duodenal balloon) avoids drawbacks of surgery (abdominal incision, narcosis) and represses weight gain.